Week 5 kicked off in exciting fashion when the Los Angeles Rams defeated the Seattle Seahawks on this week's iteration of Thursday Night Football. The slate of games on tap for this weekend should lead to some mouthwatering encounters. There are several intriguing matchups set to take place, including the NFC West showdown between the Arizona Cardinals and San Francisco 49ers, which has the potential to be the highlight of the afternoon.

Elsewhere, Justin Herbert and the Los Angeles Chargers will take on Baker Mayfield and his Cleveland Browns. Both teams enter Sunday’s showdown with a 3-1 record, and future playoff implications and tiebreakers could be on the line.

The high-point of Sunday will undoubtedly occur when the Buffalo Bills meet the Kansas City Chiefs in front of a sold-out crowd at Arrowhead Stadium. It’s the perfect follow-up to last weekend’s reunion between Tom Brady and the New England Patriots. These two teams met in the AFC Championship Game a year ago, and Sunday night’s contest between these two juggernauts could serve as a preview of what's to come in this year’s conference final.

Week 4 delivered several surprises including the New York Jets’ overtime win over the Tennessee Titans. Week 5 should continue the NFL’s undefeated trend of unpredictability. With that in mind, we’ve mustered up three bold predictions for Week 5.

BILLS EXORCISE THEIR DEMONS AGAINST THE CHIEFS

The Buffalo Bills have fielded one of the NFL's most consistent units over the past few seasons, but the Chiefs have been their kryptonite. Buffalo has lost five of their last six meetings against Kansas City dating back to 2013.

In the interest of relevancy, we'll examine Buffalo's last two losses against Kansas City, seeing that both contests were played within the past 12 months. Josh Allen, who completed an impressive 69.23% of his passes in 2020, completed just 56% of his passes in those two defeats and the Bills were well beaten and outscored to the tune of 64-41.

If Buffalo is going to reverse the curse, now is the time. The Bills have absolutely been rolling on offense since a surprising Week 1 defeat to the Pittsburgh Steelers, having scored an average of 39.3 (!) points in their last three games. On the other side of this battle sits a banged-up Kansas City defense that can’t stop a nosebleed. The Chiefs are allowing a shocking 31.3 points per contest while giving up a first down on an astounding 41.6% of their plays.

A loss in primetime would send the Chiefs to an unexpected 2-3 and we see it coming to fruition on Sunday.

JA’MARR CHASE CATCHES TWO TOUCHDOWNS

If you’re not on the Ja’Marr Chase hype train, you’re late to the party. The former LSU standout took the league by storm in the month of September by recording 17 receptions for 297 yards and four touchdowns en route to capturing NFL Offensive Rookie of the Month honors.

Chase will square off with a Packers secondary that is allowing just 209.5 passing yards per game but has yet to face a passing offense as talented as the one bubbling in Cincinnati. Chase’s penchant for reaching the end zone is going to make for a tough assignment. Look for the dominant playmaker to score a pair of touchdowns on Sunday.

LIONS GET THEIR FIRST WIN IN MINNESOTA

The Detroit Lions represent just one of two remaining winless teams (the other being Jacksonville) after four games but have played a better brand of football than most analysts expected them to. The Lions followed a heartbreaking (and perhaps unfair) Week 3 loss to the Baltimore Ravens with a 24-14 defeat at the hands of the Chicago Bears a week ago. The Lions disappointingly fell behind 21-0 in the third quarter before making a game of it late.

Dan Campbell’s men are playing hard for him, and it will lead to a win at some point—it could happen against the Vikings this Sunday. We expect Detroit to go on the road with a sense of urgency. They’ll encounter an average 1-3 Vikings team that could be without star running back Dalvin Cook due to injury.

The Lions won’t be considered the favorites by any reputable sportsbook in the country, but they should be able to compete for a win on Sunday.