The Buffalo Bills will travel to Nashville to take on the Tennessee Titans in what has the potential to be an exciting Week 6 closer. The contest will take place in front of what’s sure to be an exuberant sold-out crowd at Nissan Stadium. It’s early, but Monday night’s battle between two AFC division leaders has plenty of playoff and seeding implications on the line.

The Titans will be tasked with slowing down a Bills squad that is firing on all cylinders currently. Buffalo will bring their NFL-best scoring offense (34.4 points per game) and best-scoring defense (12.8 points allowed per contest) with them as they search for their fifth straight victory.

We have flagged three player-versus-player battles that could be decisive to determining the winner of this tasty contest.

HAROLD LANDRY VS. SPENCER BROWN

The only player to record at least five pressures in every game this season, Harold Landry has been Tennessee’s best defensive player through their first five games. On pace to easily surpass and obliterate his 2020 sack total (5), Landry has experienced a rebirth in a Tennessee defensive front that is much improved from last year’s disappointing unit.

Landry will encounter an exciting offensive tackle in rookie Spencer Brown. The third-round pick out of Northern Iowa was promoted to the Bills’ starting lineup at right tackle in place of the disappointing Cody Ford and has made the most of his early opportunities. Brown has fared admirably thus far, but will face his toughest test to date in Landry.

CALEB FARLEY VS. BILLS WRs

The Titans are entering this contest with a noteworthy injury at the cornerback position, having placed former LSU standout Kristian Fulton on injured reserve. Fulton has been Tennessee's best secondary defender and will be sorely missed against Buffalo’s fearful receivers.

We will likely see a healthy dose of first-round pick Caleb Farley for the first time this season. The No. 22 overall selection out of Virginia Tech, Farley has struggled to fully recover from a back injury that impacted his pre-draft reputation. Farley has played just 32 defensive snaps through five games, per Pro Football Focus—22 of which occurred during Tennessee’s Week 5 win over the Jacksonville Jaguars. With Fulton on the mend, the Titans will turn to Farley in an attempt to slow down Allen and the Bills' high-flying passing attack.

Farley’s baptism by fire begins against the Bills on Monday.

BILLS RUN DEFENSE VS. DERRICK HENRY

What happens when an immovable force meets an unstoppable object? Something has to give on Monday night when the league’s second-best rushing defense (78.4 yards allowed on the ground per contest) meets the league’s best pure runner. The conqueror of back-to-back rushing titles, Derrick Henry has begun the new campaign by picking up where he left off. Henry currently leads all rushers with an astounding 640 rushing yards through four games and is currently on pace to surpass the 2,000-yard rushing mark for the second consecutive season.

While Tennessee features an impressive offense of their own, their best chance to win this game may come in the form of a Henry-centered attack. If Henry finds room to operate against a stingy Bills defense, it would allow the Titans to control the clock and keep MVP-candidate Josh Allen on the sidelines, which could be imperative to their chances of success.

This is the real battle to watch.